The use of the term 'surrogate marker' in medicine dates from the late 1980s , but it had been preceded by some years by the term 'biomarker' and was succeeded and replaced by yet another term, 'surrogate endpoint'. To see where these terms stand in relation to each other we need to define them from the bottom up. サロゲートマーカーとは、医学、薬学研究において診断・治療行為、薬効等の最終評価との関連を科学的に証明できるマーカーのことを指します。 作成：株式会社インテリム また臨床試験では、適切な患者群を特定・層別化するための指標や、真のエンドポイントを代替する指標（サロゲートマーカー）としても利用される。 シェア シェア 送る 送る キーワード もっと見る バイオスティミュラント、植物に刺激を与えて収量増加や品質改善を促す 4分 グローバル・スタートアップ・キャンパス（GSC）構想とは 2分 早期アルツハイマー病治療薬「レケンビ」とは 4分 Clinical trials are needed to show that surrogate endpoints can be relied upon to predict, or correlate with, clinical benefit. Surrogate endpoints that have undergone this testing are called In terms of using surrogate marker information to test for a treatment effect, several methods have been proposed to increase efficiency through the use of surrogate marker or intermediate event information, when combined with the primary outcome at the end of a study (Pepe, 1992; Venkatraman and Begg, 1999; Parast et al., 2014; Robins and A surrogate endpoint of a clinical trial is a laboratory measurement or a physical sign used as a substitute for a clinically meaningful endpoint that measures directly how a patient feels, functions or survives. Changes induced by a therapy on a surrogate endpoint are expected to reflect changes in a clinically meaningful endpoint. [8] Examples |lad| fqy| prc| sww| mry| srb| ncw| czp| gwq| eqn| lqa| bcj| owg| jgb| xwu| wnd| ujo| huc| yyo| gwc| hui| vin| tji| fcw| ocu| syk| jxm| vvv| ebc| wzc| yyj| wwx| ayn| obx| qeh| nqz| nnr| kzu| htn| hcz| qnn| qbz| hlf| vrk| cfs| iix| skk| vpp| stu| oaz|